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Academic Article
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Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications.
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Academic Article
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DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.
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Academic Article
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Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively.
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Academic Article
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Assessment of proteasome impairment and accumulation/aggregation of ubiquitinated proteins in neuronal cultures.
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Academic Article
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Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome?
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Academic Article
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The ubiquitin/proteasome pathway: friend or foe in zinc-, cadmium-, and H2O2-induced neuronal oxidative stress.
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Academic Article
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Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2).
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Academic Article
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Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
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Academic Article
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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.
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Academic Article
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cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons.
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Academic Article
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Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.
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Academic Article
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Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential.
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Academic Article
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Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro.
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Academic Article
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Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.
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Academic Article
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Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by a- and ?-secretases: relevance to Alzheimer's disease.
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Academic Article
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Dissociation and reassociation of the bovine pituitary multicatalytic proteinase complex.
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Academic Article
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N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells.
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Academic Article
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Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation.
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Academic Article
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Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition.
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Academic Article
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A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells.
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Academic Article
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Synthetic inhibitors of the multicatalytic proteinase complex (proteasome).
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Academic Article
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Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.
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Academic Article
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A novel chymotrypsin-like component of the multicatalytic proteinase complex optimally active at acidic pH.
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Academic Article
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Aging perturbs 26S proteasome assembly in Drosophila melanogaster.
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Academic Article
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A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell.
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Academic Article
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Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates.
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Academic Article
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Aging and regulated protein degradation: who has the UPPer hand?
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Academic Article
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The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome.
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Academic Article
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Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells.
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Concept
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Protease Inhibitors
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Concept
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Cysteine Proteinase Inhibitors
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Concept
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Proteasome Endopeptidase Complex
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Academic Article
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Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes.
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Academic Article
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Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.
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